EANS-News: SYGNIS Pharma AG / SYGNIS announces financial results for fiscal year 2010/2011

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annual result

Heidelberg (euro adhoc) - SYGNIS announces financial results for
fiscal year 2010/2011

Heidelberg, 29 June 2011 - SYGNIS Pharma AG (Frankfurt:
LIOK; ISIN DE000A1E9B74; Prime Standard) today announced its
financial results for the 2010/2011 fiscal year, which ended on 31
March 2011.

Financial figures for the 2010/2011 fiscal year

• Cash including marketable securities was reduced by EUR8.7 million to
EUR6.8 million (2009/2010: EUR15.5 million). Long-term financial liabilities
amount to EUR8.0 million resulting from a loan that will not become payable
until 2015.
• Net loss for the 2010/2011 fiscal year is -EUR12.4 million compared to
-EUR10.3 million in the previous year.
• Operational expenditure increased to EUR13.0 million (2009/2010:

EUR9.2 million) due to higher expenses for the increased rate
of patient recruitment in the AXIS 2 study. • The net financial
result amounted to -EUR0.1 million (2009/2010: -EUR1.8 million)
due to unrealised losses on marketable securities.

Operational Highlights

• Positive trend of the AXIS 2 Study: In March 2011 the Data Safety
Monitoring Board (DSMB) held its third and final interim review of the
clinical efficacy study using AX200 for the treatment of acute stroke
(AXIS 2 Study) and confirmed there was no indication of any undesired or
safety-related findings. Recruitment for the study continued to improve
during second half of 2010/2011 as a result of the amendment to the study-
protocol and on 31 March 2011, 75% of the 328 patients were enrolled.
Currently more than 90% of the patients have been enrolled.
• Expanded IP-position for AX200: In February 2011, SYGNIS acquired the
exclusive rights for a European patent, which has strengthened and
prolonged the protection of AX200 for the treatment of acute stroke until
at least 2022; in addition it provides protection with regards to the
early regeneration phase after acute stroke.
• Screening for KIBRA Modulators: The Company has launched a programme to
identify suitable compounds that could have an effect on the KIBRA
pathway, which plays a key role in memory disorders, following the results
from the in vitro and in vivo "proof of principle" studies.
• Focusing on Research and Development: In the course of a corporate
restructuring process, SYGNIS decided to focus on the development of its
two main projects, AX200 and KIBRA. Furthermore, the execution of the
capital reduction by consolidating the SYGNIS shares at a ratio of 3:1 in
December 2010 improved the Company´s capital market viability.

Significant events post balance sheet date

• On 15 June 2011, the Company executed a loan agreement with its main
shareholder, dievini Hopp, amounting to EUR 6.0 million. On the basis of
the current planning, these additional funds secure the financing of
SYGNIS´ operations until the end of calendar year 2012.
• At the beginning of May 2011, the European Patent Office and the US Patent
and Trademark Office have given notice that they expect to issue
elementary KIBRA patents. The issuing of the first patents in this
important future field for the treatment of memory disorders improves the
patent position of SYGNIS and thus strengthens the value of the KIBRA
project.

Peter Willinger, SYGNIS CFO, said, "The current year will be key for
SYGNIS and we have entered it in a stronger position on a number of
fronts. Enrolment for the AX200 efficacy-study for the treatment of
acute stroke should complete soon and we expect to report the
top-line results towards the year end. According to our present
plans and including the committed financing of EUR6 million by
dievini Hopp we are in a good financial position from which to
progress the further development of our core projects."

Outlook

With respect to the research and development activities regarding the
two main projects AX200 and KIBRA, SYGNIS expects to report a net
loss and a liquidity outflow of around EUR9 million for the
current 2011/2012 fiscal year.

The key operational focus for the upcoming months is the
completion of the ongoing AXIS 2 Study and the analysis of the
related study results. Initial substantiated results are
expected to be available by the end of 2011. Dependent on
these results, the Company will then evaluate the options for any
further development of AX200. This will include a possible
out-licensing or the further development of the project with its own
resources.

SYGNIS expects to receive first results of potential candidates from
the KIBRA project in the third quarter of calendar year 2011. These
results will form the basis for upcoming research activities.

|Financial figures for financial year 2010/11 ended March 31, 2011 |
|and corresponding figures (IFRS) |
|Numbers in million EUR |2010/11 |2009/10 |
|Revenues |0.2 |0.3 |
|Total costs |13.0 |9.2 |
|EBIT |-12.8 |-8.9 |
|Result of the period |-12.4 |-10.3 |
|Intangible assets |20.8 |21.9 |
|Liquidity at year end |6.8 |15.5 |
|Equity |17.7 |30.1 |
|(equity ratio in %) |(55) |(70) |
|Long-term financial liabilities |8.0 |8.0 |
|Operational Cash Flow |-8.3 |-8.7 |

For the annual report for the fiscal year ended 31 March 2011, please visit
www.sygnis.de.

About SYGNIS Pharma SYGNIS Pharma AG, headquartered in Heidelberg,
is a specialty pharmaceutical company listed in the Prime
Standard of the Frankfurt Stock Exchange. The Company is
focused on the research and development of innovative therapies for
the treatment of disorders of the Central Nervous System. SYGNIS´
core projects are currently Acute Stroke for which SYGNIS´ lead
clinical programme is AX200, as well as the preclinical
KIBRA-project for the treatment of different forms of dementia.
All these disorders are characterized by the fact that, as the
disease progresses, nerve cells are damaged and die. Although there
is great medical demand, there are currently no or only
inadequate treatment options available. Furthermore, a key element
of the sustainable value creation of the Company is the expansion
of the product pipeline, which will be secured through its own
developments as well as in-licensing and acquisitions.

For further information please contact:
SYGNIS Pharma AG:

|Dr. Franz-Werner Haas |
|Senior Vice President Operations |
|+49 (0) 6221 454 812 |
|franz-werner.haas@sygnis.de |

Media-Contact:
Julia Phillips
Financial Dynamics
Tel.: +44 (0) 20 7269 7187

### Disclaimer Some statements included in this press release,
relating neither to proven financial results nor other historical
data, should be viewed as forward- looking, i.e. not definite.
Such statements are mainly predictions of future results, trends,
plans or goals. These statements should not be considered to be
total guarantees since given their very nature they are subject to
known and unknown risks and imponderability and can be affected by
other factors as a consequence of which the actual results, plans
and goals of SYGNIS Pharma AG may deviate greatly from the
established conclusions or implied predictions contained in such
statements. SYGNIS does not undertake to publicly update or revise
these statements in the light of new information or future results
or for any other reason. ###

Further inquiry note:
Michael Wolf
Telefon: +49 (6221) 454 - 6
E-Mail: Michael.Wolf@sygnis.de

end of announcement euro adhoc
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company: SYGNIS Pharma AG
Im Neuenheimer Feld 515
D-69120 Heidelberg
phone: +49 (0)6221 454-6
FAX: +49 (0)6221 454-777
mail: contact@sygnis.de
WWW: http://www.sygnis.de
sector: Biotechnology
ISIN: DE000A1E9B74
indexes: CDAX, Prime All Share
stockmarkets: regulated dealing/prime standard: Frankfurt, free trade: Berlin,
Hamburg, Stuttgart, Düsseldorf, Hannover, München
language: English