Omega-3 fatty-acid enriched parenteral nutrition improves patient outcomes

BAD HOMBURG, GERMANY (ots) - A new systematic literature review and
meta-analysis1 confirms and extends previous results that omega-3 (omega-3)
fatty-acid enriched parenteral nutrition (PN) improves clinical outcomes
compared with standard PN in adult patients. Including a total of 49 randomized
controlled trials (RCTs), this literature review provides the most extensive and
up-to-date analysis* of the effect of omega-3 fatty-acid enriched PN on patient
outcomes.

According to this analysis, adding omega-3 fatty acids to PN significantly
reduces the risk of infections by 40 % and the length of ICU and hospital stays
by two days compared with standard PN. Moreover, the analysis revealed that PN
enriched with fish oil significantly reduces sepsis by 56 %. An analysis of RCTs
reporting laboratory parameters furthermore suggests that omega-3 fatty-acid
enriched PN can have beneficial effects on liver chemistry, antioxidant status,
markers of inflammation, and the fatty-acid profile. The authors conclude that
lipid emulsions enriched with omega-3 fatty acids should be preferred over
standard lipid emulsions in patients needing PN.

About the review and meta-analysis

The meta-analysis by Lorenzo Pradelli and colleagues was published in the
Journal of Parenteral and Enteral Nutrition in June 2019. The review includes a
total of 49 RCTs with 3641 adult hospital patients comparing outcomes between
groups receiving omega-3 fatty-acid enriched lipid emulsions and groups
receiving standard lipid emulsions as part of PN. Only those RCTs were included,
in which PN accounted for at least 70 % of the patients' daily energy provision.
RCTs with off-label interventions were excluded from the analysis.

For more information you can find the full publication at
https://onlinelibrary.wiley.com/doi/full/10.1002/jpen.1672

* Authors qualify this statement as being "...to the best of our knowledge..."

References

1. Pradelli L, Mayer K, Klek S et al. omega-3 Fatty-Acid Enriched Parenteral
Nutrition in Hospitalized Patients: Systematic Review With Meta-Analysis and
Trial Sequential Analysis. JPEN J Parenter Enteral Nutr. 2019.

About Fresenius Kabi

Fresenius Kabi is a global healthcare company that specializes in lifesaving
medicines and technologies for infusion, transfusion and clinical nutrition. The
company's products and services are used to help care for critically and
chronically ill patients. Fresenius Kabi's product portfolio comprises a
comprehensive range of I.V. generic drugs, infusion therapies and clinical
nutrition products as well as the devices for administering these products. In
the field of biosimilars, we focus on autoimmune diseases and oncology. In 2019,
the first biosimilar product by Fresenius Kabi was launched. Within transfusion
medicine and cell technologies, Fresenius Kabi offers products for collection
and processing of blood and cell components.

With its corporate philosophy of "caring for life", the company is committed to
putting essential medicines and technologies in the hands of people who help
patients and finding the best answers to the challenges they face.

Fresenius Kabi employs more than 37,000 people worldwide. In 2018, the company
reported sales of more than EUR6.5 billion. Fresenius Kabi AG is a wholly owned
subsidiary of Fresenius SE & Co. KGaA healthcare group.

For more information, visit the company's website at
https://www.fresenius-kabi.com.

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Nina Espiritu
Edelman GmbH
Barmbeker Str 4, 22303 Hamburg, Germany
T +49 (0)69 401254-345
nina.espiritu@edelman.com

Original-Content von: Fresenius Kabi Deutschland GmbH, übermittelt durch news aktuell