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Intercell AG announces Q1 results and update on development programs:

Geschrieben am 14-05-2007

Adjuvant IC31TM opens attractive new market opportunity in Flu – All
development projects on track – Strong focus on nosocomial infections
–– Net loss further decreased – Strong financial position


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finances

Wien (euro adhoc) - IC31TM - Clinical results emphasize broad and
commercial use in vaccine development

» Protective profile for IC31TM in Phase I Tuberculosis vaccine trial
- strong T-cell immune responses in humans confirming broad
pre-clinical data base » Promising pre-clinical data for the use of
IC31TM in next generation Flu vaccines - first clinical trials
planned for 2007 » Next Milestones - start of a Phase I
"proof-of-concept" clinical trial for an IC31TM adjuvanted Flu
vaccine and strong focus on a commercial use of IC31TM and further
strategic partnerships

All development projects on track and within expected timelines

» Japanese Encephalitis vaccine - all preparations for expected
market launch in the US early 2008 and late 2008 in Europe are on
track Regulatory clearance to start a pediatric Phase II clinical
trial in India obtained - start of Phase II trial within the next
few weeks » Hepatitis C vaccine - Phase II "proof-of-concept" study
fully recruited - first data expected by mid 2007 - forward
strategies comprise options for mono- and/or combination therapies
» Pneumococcus vaccine - preparations for start of Phase I clinical
trial on track

Nosocomial (hospital-acquired) infections - Building the leading
vaccine franchise

» Staphylococcus aureus vaccine partnered with Merck & Co. - safe and
immunogenic in Phase I clinical trials - Phase II expected to start
in 2007 » Pseudomonas vaccine - preparations for start of clinical
Phase II/III trials on track » Enterococcus/Klebsiella vaccines -
AIP® accelerated to progress into clinical development

Strong financial position - Net loss further reduced » EUR 7.1
million net loss for Q1 2007 - down 19.3 percent as compared to Q1
2006 » Increase of aggregate revenues - EUR 1.5 million in Q1 2007
compared to EUR 0.3 million in Q1 2006 » EUR 7.4 million R&D
expenses in Q1 2007 - up 8.8 percent as compared to Q1 2006 »
Strong cash position with EUR 86.3 million in liquid funds at March
31, 2007

Vienna (Austria), May 14, 2007 - Vaccine company Intercell AG (VSE:
ICLL) announced today the financial results for the first quarter
2007 and an update on the company´s development programs:

Q1 2007 Operational Business and Strategy Review

Japanese Encephalitis (JE) vaccine on track to market:

The regulatory process towards a Biologics License Application (BLA)
to the U.S. Food and Drug Administration (FDA) has been initiated.

In Q1 2007 Intercell and its Indian partner Biological E. Ltd.
obtained regulatory clearance to start a pediatric Phase II clinical
trial for Intercell´s novel Japanese Encephalitis vaccine in India.
The study, which is expected to start within the next few weeks, will
enroll children at the age of one to three years. It is the first
step towards the licensure of a new cell culture derived product in
Asia, which is expected by late 2008/early 2009.

Next Milestones:
» EMEA filing
» Agreement with US Army
» Market launch (early 2008)
» Marketing and sales agreement for Japanese market

Hepatitis C vaccine - Phase II "proof-of-concept" study fully
recruited:

The recruitment of the Phase II study with 50 treatment naïve chronic
Hepatitis C patients was completed in Q1 2007. The patients were
vaccinated with Intercell´s vaccine IC41, using an optimized route
and frequency of administration, which was identified in an
optimization study completed during 2006.

The current study aims to show significant reductions of HCV-RNA
linked to the stronger HCV specific T-cell responses obtained in the
optimization study. First interim data from the ongoing Phase II
study comprising a first subset of patients having already completed
all 8 vaccinations given during a 14 weeks treatment period are
expected by mid 2007. Final data of the study are expected to be
available by early 2008. Forward strategies for further development
comprise options for mono- and/or combination therapies.

Next Milestone:
» Interim and final Phase II data

IC31TM - Human data open new opportunities for Flu and other
vaccines:

IC31TM, which is used as adjuvant in a Tuberculosis vaccine partnered
with SSI, delivered an outstanding profile in a Phase I study
completed in Q1 2007. IC31™ demonstrated the stimulation of strong
T-cell immune responses in humans as had already previously been seen
in a variety of animal models. These results underpin the scientific
concept of IC31™ and encourage broad and commercial use of
Intercell´s proprietary technology platform in a variety of
prophylactic and therapeutic vaccines.

Supported by the Tuberculosis vaccine data obtained in humans and
based on the broad Flu-specific B- and T-cell immunogenicity profile
observed in animal models (presented at "Influenza Vaccines for the
World", Vienna, October 2006), a Phase I clinical trial to
demonstrate the "proof-of-concept" for a superior inter-pandemic
vaccine formulated with IC31TM, is planned to commence in the second
half of 2007.

With one single injection of a standard Flu vaccine adjuvanted with
IC31™ Haemaglutinin titers and specific T-cell responses could be
drastically increased in a mouse immunogenicity model. Furthermore,
the presence of IC31™ induces very long-lasting and high levels of
Flu-specific T-cells as well as IgG2a, both markers for a type 1
response known to improve and to broaden the protection from
Influenza infections.

Next Milestones: » Start of a Phase I "proof-of-concept" clinical
trial for an IC31TM adjuvanted Flu vaccine » Strong focus on a
commercial use of IC31TM and further strategic partnerships

Tuberculosis vaccine - Phase I data justify product development:

In Q1 2007, Intercell and its partner, the Danish Statens Serum
Institut (SSI), announced positive results for their Tuberculosis
vaccine. The vaccine combines SSI´s antigens with Intercell´s
proprietary adjuvant IC31TM. The data from the Phase I trial, which
was performed at the Department of Infectious Diseases at Leiden
University Medical Center in the Netherlands, show that the vaccine
is safe and very immunogenic in healthy individuals as reported at
the Keystone conference April 2007. Based on these results, the start
of further Phase I/II clinical trials is planned for 2007.

Next Milestone:
» Start of further clinical trials (with SSI)

Q1 2007 Financial review

Revenues: Aggregate revenues increased from EUR 0.3 million in the
three months ended March 31, 2006 to EUR 1.5 million in the three
months ended March 31, 2007. The increase was attributable to higher
grant income and to higher revenues from existing collaboration and
licensing agreements with pharmaceutical companies.

Results of Operations: Intercell´s net loss decreased from EUR 8.8
million in the first quarter 2006 to EUR 7.1 million the first
quarter 2007, or by 19.3 percent. This decrease was primarily due to
an increase in revenues and in other operating income and to a
decrease in the share of loss of associated companies.

Net operating expenses increased from EUR 8.7 million in the quarter
ended March 31, 2006 to EUR 9.0 million in the quarter ended March
31, 2007, or by 3.4 percent. Research and development expenses
increased by 8.8 percent and were EUR 7.4 million in the first three
months of 2007 compared to EUR 6.8 million the same period of 2006.
Intercell´s general, selling and administrative expenses were EUR 3.2
million in the three months ended March 31, 2007 compared to EUR 2.0
million in the comparative period of the previous year. This increase
of 60.0 percent was primarily due to higher personnel expenses
resulting from stock compensation costs. Net other operating income
increased from EUR 0.1 million in the first quarter 2006 to EUR 1.6
million in the first quarter 2007 due to primarily R&D tax credits.

No share of loss of associated companies was recorded in the three
months ended March 31, 2007, compared to EUR 1.0 million in the same
period of the previous year, because all companies that had been
accounted for as associates had been acquired and were fully
consolidated. The contribution of newly acquired companies to
Intercell´s net loss in the first quarter 2007 was EUR 0.7 million.

Net financial income decreased from EUR 0.5 million in the first
quarter 2006, to EUR 0.4 million in the same period of 2007 due to
higher interest expenses, which were partly offset by higher interest
income.

Cash Flow: Intercell´s net cash used in operating activities for the
quarters ended March 31, 2007 and 2006 was EUR 9.6 million and EUR
8.5 million, respectively. The increase was primarily due to higher
working capital requirements.

Net cash provided by investing activities in the first quarter of
2007 was EUR 1.3 million compared to EUR 9.2 million in the same
period of the previous year. The decrease was primarily due to the
prior year´s effect of the sale of available-for-sale financial
assets in the first quarter of 2006. Cash used for purchases of
property, plant and equipment increased to EUR 1.8 million in the
three months ended March 31, 2007 from EUR 1.4 million in the first
quarter of 2006 and was primarily used for laboratory and
manufacturing equipment. In the first quarter of 2007, Intercell
acquired essentially all of the shares of Pelias Biomedizinische
Entwicklungs AG in an all-share deal. The transaction added EUR 2.9
million in cash to Intercell´s balance sheet and, according to IAS
36, led to the capitalization of in-process research and development
projects of EUR 18.9 million.

Intercell´s net cash used in financing activities in the period ended
March 31, 2007 was EUR 0.5 million, compared to EUR 0.3 million in
the same period of the previous year, and resulted primarily from
repayments of loans. As of March 31, 2007 Intercell had liquid funds
of EUR 86.3 million of which EUR 20.2 million was cash and cash
equivalents and EUR 66.1 million was available-for-sale financial
assets. Key Financial Figures


EUR in thousands 3 months ended March 31 Year ended December 31,
2006
2007 2006

Revenues 1,502 372 23,452
Net loss (7,050) (8,814) (16,143)
Net operating
cash flow (9,635) (8,482) (7,979)
Cash and


marketable
securities,
end of period 86,262 38,817 94,421

The un-audited condensed consolidated interim financial statements
can be downloaded at www.intercell.com.


end of announcement euro adhoc 14.05.2007 07:35:00
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ots Originaltext: Intercell AG
Im Internet recherchierbar: http://www.presseportal.de

Further inquiry note:
Intercell AG
Mag. Katharina Wieser
Head of Corporate Communications
Tel. +43 1 20620-303
kwieser@intercell.com

Branche: Biotechnology
ISIN: AT0000612601
WKN: A0D8HW
Börsen: Wiener Börse AG / official market


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