New Data to be Presented at the European Academy of Neurology (EAN) Congress 2015 Highlights Eisai's Commitment to Its Leading Epilepsy Portfolio

Hatfield, England (ots/PRNewswire) -

PRESS RELEASE FOR EU MEDIA ONLY: NOT FOR SWISS/AUSTRIAN/US
JOURNALISTS

Eisai is proud to present key data from its epilepsy portfolio,
the largest of its kind in the Europe, at the first European Academy
of Neurology Congress (EAN) in Berlin, Germany. Eisai presents data
on the efficacy of adjunctive Fycompa(R) (perampanel) in idiopathic
generalised epilepsy via oral and poster presentations.

"Epilepsy is a challenging condition to manage, it is therefore
important that we strive to find effective treatments to support
people with epilepsy. These new data at EAN 2015 reinforce Eisai's
investment in new epilepsy treatment options with the potential to
improve outcomes in different patient populations," comments Neil
West, Vice President, Global Neurology Business Unit, Eisai EMEA.

The following abstracts are accepted for presentation at the EAN
congress:

Abstract Number Abstract details
Perampanel

Abstract number: #1362 Efficacy of adjunctive perampanel in idiopathic
Monday 22 June generalised epilepsy: Subgroup analysis of patients with
12:30-13:15 absence and myoclonic seizures in a double-blind
Screen B1, P3139 placebo-controlled Phase 3 trial
Terence J O'Brien, Bernhard J Steinhoff, Haichen Yang,
Antonio Laurenza, Anna Patten, Francesco Bibbiani

Abstract number: #393 Efficacy of adjunctive perampanel in idiopathic
Sunday 21 June generalised epilepsy patients with drug-resistant primary
14:14-16:15 generalised tonic-clonic seizures by age, sex, race:
Hall A2, O2112 Double-blind PBO-controlled Phase 3 trial
Bernhard J Steinhoff, Terence J O'Brien, Haichen Yang,
Antonio Laurenza, Anna Patten, Francesco Bibbiani

The continued development of its epilepsy portfolio underscores
Eisai's human health care (hhc) mission, the company's commitment to
innovative solutions in disease prevention, cure and care for the
health and wellbeing of people worldwide. Eisai is committed to the
therapeutic area of epilepsy and to address the unmet medical needs
of people with epilepsy and their families. Eisai is proud to
currently market more epilepsy products in EMEA than any other
company.

Notes to Editors

About Fycompa(R) (perampanel)

Perampanel is indicated for the adjunctive treatment of partial
onset seizures, with or without secondarily generalised seizures, in
patients with epilepsy aged 12 years and older.[1]

Perampanel is a highly selective, non-competitive AMPA (
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid)-type
glutamate receptor antagonist that has demonstrated seizure reduction
in Phase II and III studies. AMPA receptors, widely present in almost
all excitatory neurons, transmit signals stimulated by the excitatory
neurotransmitter glutamate within the brain and are believed to play
a role in central nervous system diseases characterised by excess
neuroexcitatory signalling including epilepsy.[1]

For further information please visit: http://www.fycompa.eu

About Epilepsy

Epilepsy is one of the most common neurological conditions in the
world, affecting approximately 6 million people in Europe, and an
estimated 50 million people worldwide.[1],[2] Epilepsy is a chronic
disorder of the brain that affects people of all ages. It is
characterised by abnormal discharges of neuronal activity which
causes seizures. Seizures can vary in severity, from brief lapses of
attention or jerking of muscles, to severe and prolonged convulsions.
Depending on the seizure type, seizures may be limited to one part of
the body, or may involve the whole body. Seizures can also vary in
frequency from less than one per year, to several per day. Epilepsy
has many possible causes but often the cause is unknown.

About Eisai EMEA in Epilepsy

Eisai is committed to developing and delivering highly beneficial
new treatments to help improve the lives of people with epilepsy. The
development of AEDs is a major strategic area for Eisai in Europe,
the Middle East, Africa, Russia and Oceania (EMEA).

In the EMEA region, Eisai currently has four marketed treatments
including:

- Fycompa(R) (perampanel) for the adjunctive treatment for partial onset
seizures, with or without secondarily generalised seizures, in patients with epilepsy
aged 12 years and older
- Zebinix(R) (eslicarbazepine acetate) as adjunctive therapy in adults with
partial onset seizures, with or without secondary generalisation (Zebinix is under
license from BIAL)
- Zonegran(R) (zonisamide) as monotherapy in the treatment of partial seizures,
with or without secondary generalisation, in adults with newly diagnosed epilepsy and
as adjunctive therapy in the treatment of partial seizures, with or without secondary
generalisation, in adults, adolescents, and children aged 6 years and above (Zonegran
is under license from the originator Dainippon Sumitomo Pharma)
- Inovelon(R) (rufinamide) for the adjunctive therapy in the treatment of
seizures associated with Lennox-Gastaut syndrome (LGS) in patients four years of age
and older (Rufinamide was originally developed by Novartis)

About Eisai Co Ltd

Eisai Co., Ltd. is a leading global research and development-based
pharmaceutical company headquartered in Japan. We define our
corporate mission as "giving first thought to patients and their
families and to increasing the benefits health care provides," which
we call our human health care (hhc) philosophy. With over 10,000
employees working across our global network of R&D facilities,
manufacturing sites and marketing subsidiaries, we strive to realise
our hhc philosophy by delivering innovative products in multiple
therapeutic areas with high unmet medical needs, including oncology
and neurology.

As a global pharmaceutical company, our mission extends to
patients around the world through our investment and participation in
partnership-based initiatives to improve access to medicines in
developing and emerging countries.

For more information about Eisai Co., Ltd., please visit
http://www.eisai.com.

References

1. Epilepsy in the WHO European Region: Fostering Epilepsy Care in
Europe.
http://www.ibe-epilepsy.org/downloads/EURO%20Report%20160510.pdf
(Accessed June 2015)

2. Pugliatti M et al. Estimating the cost of epilepsy in Europe: A
review with economic modeling. Epilepsia 2007:48(12):2224-33

Date of preparation: June 2015

Job code: Perampanel-UK2192

ots Originaltext: Eisai
Im Internet recherchierbar: http://www.presseportal.de

Contact:
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Neal/Deepa
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Elisabeth.Neal@toniclc.com,
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